NanoRAM: Emerging Nanotools for Soft Matter Characterisation and Manipulation

包括原子力显微镜、光学显微镜和相关显微镜在内的先进纳米工具是纳米科学和技术发现和知识生成的使能技术。许多研发工作都是针对软物质的这类技术的性能改进。然而，这些前沿技术面临的最大挑战是实现高时空分辨率、无创、多尺度和多维成像和操作。因此，我们提出NanoRAM，一个由学术界和工业界合作伙伴围绕创新纳米工具及其工业应用的主题密切合作的10 ESR Marie Sklodowska居里行动博士网络。NanoRAM将培养新一代的esr在软物质研究中开发和应用新开发的操作和表征纳米工具。ESRs将与仪器仪表和软物质表征的概念和技能交叉授粉，特别是在快速纳米力学光谱，纳米机器人，相关的超分辨率纳米显微镜，纳米生物力学和机械转导方面。这些技术的应用首次揭示了单细胞生物力学和纳米医学的快速、高分辨率、多层次和三维信息。在新的科学和互补技能方面的优秀培训，加上国际和部门间的工作经验，将在ESRs中灌输创新、创造和创业的心态，最大限度地提高科学发现的经济效益。这些专业的、训练有素的社会服务人员将大大提高在私营和公共部门担任责任职位的职业前景和资格。NanoRAM的最终目标是巩固欧洲在创新纳米工具技术及其在软物质领域（如生物力学、机械生物学和纳米医学）新兴应用方面的世界领先地位。

Advanced nanotools including atomic force microscopy, optical microscopy and correlative microscopy are enabling techniques for discoveries and knowledge generation in nanoscale science and technology. Many R&D efforts have been directed towards the performance improvement of such kinds of techniques for soft matter. However, the greatest challenge faced by these leading edge techniques is the realization of high spatiotemporal resolution, non-invasive, multi-scale and multi-dimensional imaging and manipulation. We therefore propose NanoRAM, a 10 ESR Marie Sklodowska Curie Action Doctoral Network by close collaboration between academic and industrial partners around the theme of innovative nanotools and their industrial applications. NanoRAM will train a new generation of ESRs in the development and application of newly developed manipulation and characterisation nanotools in soft matter research. ESRs will be cross-pollinated with concepts and skills in instrumentation and soft matter characterisation, in particular in fast nanomechanical spectroscopy, nano-robotics, correlative super-resolution nanoscopy, nano biomechanics and mechanotransduction. These skills are applied to reveal for the first time the fast, high resolution, multi-level and 3D information forsingle cell biomechanics and nanomedicine. Excellent training in new scientific and complementary skills, combined with international and intersectoral work experience, will instil an innovative, creative and entrepreneurial mind-set in ESRs, maximising economic benefits based on scientific discoveries. These specialised, highly trained ESRs will have greatly enhanced career prospects and qualifications for access to responsibility job positions in the private and public sectors. The ultimate goal of NanoRAM is to consolidate Europe as the world leader in innovative nanotool techniques and their emerging applications in soft matter fields such as biomechanics, mechanobiology, and nanomedicines.