CLINICAL AND THERAPEUTIC STUDIES OF THE RHEUMATIC DISEASES

我们进行了一系列的临床调查， 系统性红斑狼疮-一种慢性，复发和缓解 以免疫介导的炎症为特征的疾病。 当前 研究主要集中在狼疮性肾小球肾炎患者， 试图评估与治疗有关的实际问题， 烷基化剂环磷酰胺，特别是研究新的 疾病管理的方法。 可行性研究表明， 大剂量口服环磷酰胺的门诊治疗是安全的， 一种有效的和改进的方案， 恶心已经被研究过了。 小鼠单克隆抗体的小规模初步研究 6例患者的抗CD5蓖麻毒素A链免疫偶联物记录了慢性 外周T细胞群减少，有临床证据 狼疮性肾炎的症状有哪些？

We have conducted a series of clinical investigations involving patients with systemic lupus erythematosus - a chronic, relapsing and remitting disorder characterized by immune-mediated inflammation. The current studies have mainly focused on patients with lupus glomerulonephritis in an attempt to assess practical issues related to therapy with the alkylating agent cyclophosphamide and, in particular, to investigate new approaches to disease management. A feasibility study has demonstrated that outpatient therapy with bolus oral cyclophosphamide is safe and effective and an improved regimen for minimizing cyclophosphamide-induced nausea has been studied. A small pilot study of a murine monoclonal anti-CD5 ricin A chain immunoconjugate in 6 patients documented a chronic reduction in peripheral T cell populations with evidence of clinical improvement in two patients with lupus nephritis.