International Centre of Excellence in the Treatment of Pathological Fractures

国际中心到中心的合作侧重于这三所大学的一个重要研究活动领域：病理性骨折。随着人口老龄化，骨折发生率预计将激增，因此构成了一个紧急的、未得到满足的临床需求。最近，首席研究人员与临床医生和患者共同创建和参与的活动指出，需要优化的、针对患者的微创方法、骨折预防和局部治疗药物的使用，以减少感染、疾病负担和改善骨骼质量/固定。中心的目标是响应这一临床需求，并在这三个机构现有的实质性协同作用的基础上发展一个国际病理性骨折研究英才中心。其中包括：利兹大学(UOL)：医疗器械高级评估，在骨转移引起的脊柱骨折(EPSRC计划拨款：肿瘤工程)和假体周围骨折(Zimmer-Biomet)的研究上投入了大量资金。Uppsala大学：生命科学的添加剂制造(VINNOVA资助的能力中心)和软骨(EIT Health资助的)新一代低模数材料，旨在固定和预防椎骨骨折以及增强椎间盘。苏黎世大学：病理性骨折的高级成像和建模(新加坡)和转移性疾病的骨折建模(欧盟资助的METASTRA)。我们将把这些属性结合在一起，形成更全面的、更全面的多学科合作将显著扩大通过我们的工业和医疗合作伙伴产生新的支撑工程科学和适当影响的范围。我们的目标是：(1)一个集成的、多尺度的骨折预测模型框架，以识别在特定病理情况下有骨折风险的骨骼。为了帮助预防性干预措施降低这种骨折风险并实现特定于病理的方法，B.利用建模来改进针对患者的/定制植入物的设计。开发自ETHZ和UOL的研究。(2)开发一个可预防性的、特定于病理学的、微创干预措施的框架，以支持承重骨并防止骨折，从而A.在目标1b中开发的建模的辅助下，显著抑制不稳定性、骨痛和在椎骨中脊髓损伤的可能性。开发髋关节假体周围骨折的工具和干预措施。开发基于Uppsala生命能力中心的添加剂制造和Softbone和UOL的研究。(3)专门针对治疗要求的新一代创新涂层，包括减少感染和疾病负担、促进骨骼生长和增强固定。利用目标1和目标2中概述的材料和水泥技术，以提供更好的功能结果。基于Uppsala和UOL的研究，该提案以一系列交叉主题为基础，这些主题是：(1)负责任的创新是这项活动的核心，并包括适当的(A)伦理原则，确保研究惠及包括患者在内的更广泛的利益相关者，(B)患者和临床共同创造和有意义的互动，以加强整体设计过程和(C)增强影响的适当机制，包括传播、持续的患者参与和开发。(2)劳动力发展，以确保研究人员和研究人员都拥有成功进行研究的适当知识和更广泛的职业抱负。(3)研究人员和患者双方的平等、多样性和包容性。

The International Centre-to-Centre collaboration focuses on a significant area of research activity at the three Universities: Pathological Fractures. Fracture rates are expected to surge as the population ages and therefore constitute an urgent, unmet clinical need. Recent co-creation and engagement activities, by the principal investigator, with clinicians and patients, has noted the need for optimised, patient-specific minimally invasive approaches, fracture prevention and the use of localised delivery of therapeutic agents to reduce infection, disease burden and improve bone quality/fixation.The aim of the Centre-to-Centre is to respond to this clinical need and develop an International Centre of Excellence in Research of Pathological Fractures building on the substantial synergies that exist at the three institutions. These include:University of Leeds (UoL): Advanced assessment of medical devices, substantial investments in research for spinal fracturesarising from bone metastases (EPSRC Programme Grant: Oncological Engineering) and peri-prosthetic fractures (Zimmer-Biomet).Uppsala University: Additive Manufacturing for the Life Sciences (VINNOVA funded Competence Centre) and Soft Bone (EIT Health funded) a new generation of low modulus materials designed to fix and prevent fractures in the vertebrae as well as augmentation of the disc.ETH Zurich: Advanced imaging and modelling for pathological fractures (FHT Singapore) and fracture modelling in metastatic disease (EU funded METASTRA).We have further support from 4 industrial partners and UoL.We will bring these attributes together into a more holistic, multidisciplinary collaboration that would significantly enhance the scope for generating novel underpinning engineering science together with appropriate impact through our industrial and healthcare partners.The objectives, building on and enhancing the activities outlined above, are:(1) An integrated, multiscale, Fracture Prediction Modelling Framework to identify bones that are at risk of fracture in given pathologies so as.a. to aid prophylactic interventions to reduce this fracture risk and enable pathology-specific approaches,b. utilise modelling to improve the design of patient-specific/custom made implants.Developed from research at ETHZ and UoL.(2) Develop a Framework for Prophylactically Amenable, Pathology-Specific, Minimally-Invasive interventions to support the load-bearing bone and prevent fracture so to a. significantly inhibit instability, bone pain and, in the vertebra, the potential for spinal cord injury, with the aid of the modelling developed in objective 1b. develop tools and interventions for hip peri-prosthetic fracture.Developed from the research at Uppsala in the Additive Manufacturing for Life Competence Centre and SoftBone and the UoL.(3) A new generation of innovative coatings specific to treatment requirements including reduction in infection & disease burden, promotion of bone growth and enhanced fixation.a. to take advantage of the material and cement technologies outlined in objectives 1 and 2 to provide better functional outcomes.Based on the research at Uppsala and UoL.The proposal is underpinned by a set of cross-cutting themes which are:(1) Responsible Innovation is central to this activity and includes the appropriate (a) ethical principles ensuring that theresearch benefits a wider set of stakeholders including patients, (b) patient and clinical co-creation and meaningfulinteractions so as to enhance the overall design process and (c) appropriate mechanisms that enhance impact includingdissemination, continued patient engagement and exploitation.(2) Workforce development, to ensure that both researchers and investigators have the appropriate knowledge forthe successful execution of the research and wider career aspirations.(3) Equality, Diversity and Inclusion, of both the researchers and the patients involved.