ROLES OF DNA DEMETHYLATION AND CYTOTOXIC EFFECT IN HIV EXPRESSION

该项目仍在进行中，但尚未进行重大研究。 人类免疫缺陷病毒型的显著临床特征之一 1(HIV-1)感染是相对较长的潜伏期，即 以病毒的低表达或检测不到为特征的，如下 病毒血症感染的早期急性阶段。然而，这些机制 负责维持这一临床潜伏期的人到目前为止 人们对此知之甚少。在延长的潜伏期或无症状期间， 在外周血液中只检测到少数感染细胞。这可能是 由于宿主的免疫有效地清除了表达HIV-1的细胞 感染早期的防御机制。然而，身份不明的人 抑制病毒表达的机制(S)也可能是可操作性的 在感染的早期阶段的感染者中。

This project is still open; however no significant studies have been done. One of the salient clinical features of human immunodeficiency virus type 1 (HIV- 1) infection is the relatively long period of latency which is characterized by a low to undetectable expression of the virus, following an early acute phase of infection with viremia. However, the mechanisms responsible for the maintenance of this clinical latency have been as yet poorly understood. During the extended latency or asymptomatic period, only a few infected cells are detected in peripheral blood. This may be due to an efficient removal of HIV-1-expressing cells by the host's immune defense mechanisms at early stages of infection. However, yet unidentified mechanism(s) to suppress the expression of the virus may also be operative in infected individuals at the early stages of infection.