PROFILES OF DRUG SENSITIVITY OF HIV-1 ISOLATES IN PATIENTS RECEIVING ANTIVIRALS

接受抗病毒药物治疗的患者中 HIV-1 分离株的药物敏感性概况

• 批准号: 3838136
• 负责人: H MITSUYA
• 金额: --
• 依托单位: DIVISION OF CANCER TREATMENT
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3838136
• 关键词: AIDS; RNA directed DNA polymerase; dosage; drug resistance; human immunodeficiency virus 1; human tissue; nucleic acid sequence; tissue /cell culture; zidovudine

The ability to provide effective long-term antiretroviral therapy using single agents for human immunodeficiency virus type 1 (HIV-1) infection became a complex issue when the isolation of HIV-1 strains that were less sensitive to 3'-azido-2',3'-dideoxythymidine (AZT or zidovudine) in vitro from patients with acquired immunodeficiency syndrome (AIDS) who received AZT therapy for more than 6 months was reported in 1989. Nucleotide sequence analysis of the reverse transcriptase-coding region from pairs of AZT-sensitive and -resistant HIV-1 isolates have revealed several mutations that result in amino acid substitutions in the viral reverse transcriptase. These amino acid substitutions include: (i) Asp at amino acid position-67 to Asn (designated Asp-67 -> Asn); (ii) Lys-70 -> Arg; (iii) Thr-215 -> Tyr or Thr-215 -> Phe; and (iv) Lys-219 -> Gln.

使用抗逆转录病毒药物提供长期有效治疗的能力 用于人类免疫缺陷病毒1型（HIV-1）感染的单一药物 成为一个复杂的问题时，分离的HIV-1菌株， 体外对叠氮胸苷或齐多夫定敏感 获得性免疫缺陷综合征（艾滋病）患者， 1989年报告了6个月以上的AZT治疗。 核苷酸 逆转录酶编码区的序列分析 AZT敏感和耐药的HIV-1分离株显示， 在病毒逆转中导致氨基酸取代的突变 录酶 这些氨基酸取代包括：（i）氨基上的Asp （ii）Lys-70 -> Arg; (iii)Thr-215 -> Tyr或Thr-215 -> Phe;和（iv）Lys-219 -> Gln。