INHIBITION OF HEPATITIS B VIRUS REPLICATION BY DIDEOXYNUCLEOSIDES

双脱氧核苷对乙型肝炎病毒复制的抑制

• 批准号: 3838139
• 负责人: H MITSUYA
• 金额: --
• 依托单位: DIVISION OF CANCER TREATMENT
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3838139
• 关键词: 2'3' dideoxynucleoside; antiviral agents; hepatitis B virus group; virus replication

During the last decade, a great deal has been learned about the replicative cycle of human hepatitis B virus (HBV), a DNA virus that causes acute and chronic hepatitis, liver cirrhosis, and hepatocellular carcinoma. The latter complication causes over one million deaths worldwide every year. Although there are there is at least a number of distinct differences between HBV and HIV, one notable resemblance between these two human pathogenic viruses in that their replicative cycle involves an obligate RNA intermediate and a reverse transcription step in the cytoplasm.

在过去的十年里，人们已经了解了很多关于 人类乙肝病毒(乙肝)的复制周期，一种DNA病毒 导致急性和慢性肝炎、肝硬变和肝细胞癌 癌症。后一种并发症导致100多万人死亡。 每年在全球范围内。尽管有至少有一些 乙肝病毒和艾滋病毒之间的明显区别，一个显著的相似之处是 这两种人类致病病毒的复制周期 涉及专有的RNA中间体和反转录步骤 细胞质。