STUDIES OF THYROID DISEASES

招募高危甲状腺癌患者接受综合治疗 I-131和小剂量阿霉素已经停止使用，因为 转诊的数量不足以评估治疗效果 有效性。然而，综合治疗仍在继续，有8名患者。 随机分配到这个治疗组和毒性将被评估和 与只接受I-131的对照组相比。毒性数据将是 对治疗建议很重要。 重组人促甲状腺激素在近期甲状腺手术中的I/II期研究 癌症患者已经完成，结果正在评估中。 由于初步结果令人鼓舞，目前正在进行第三阶段的研究 患者处于疾病的不同阶段。这一多机构 这项研究是与布鲁斯·温特劳布和Genzyme公司合作进行的， 并有望改进对残留或复发的甲状腺的检测 癌症。 结合流行病学研究的发展，以评估 受此影响的儿童甲状腺癌发病率明显增加 切尔诺贝利核电站事故，举行研讨会评估 随之而来的一些临床管理问题。得出的结论是， 这些儿童的攻击性行为具有以下特点 甲状腺癌在这个年龄段并不是辐射的结果。确实是 还得出结论，L-甲状腺素对慢性粒细胞白血病的潜在预防治疗 目前还没有显示出广泛的规模。

Recruitment of high risk thyroid cancer patients for combination therapy with I-131 and low dose doxorubicin has been discontinued because the number of referrals has been insufficient to evaluate therapeutic effectiveness. Combined therapy is continuing, however, with 8 patients randomized to this treatment arm and toxicity will be evaluated and compared with controls who received I-131 alone. The toxicity data will be important for therapy recommendations. The phase I/II study of recombinant human TSH in recently operated thyroid cancer patients has been completed and the results are being evaluated. Because of encouraging initial results a phase III study is now underway with patients in varying stages of their disease. This multi-institutional study is in collaboration with Bruce Weintraub and the Genzyme Corporation, and is expected to improve testing for residual or recurrent thyroid cancer. In conjunction with development of epidemiological studies to evaluate the apparent increased incidence of thyroid cancer in children affected by the nuclear power plant accident in Chernobyl, a workshop was held to evaluate some clinical management problems that ensued. It was concluded that the aggressive behavior of the disease in these children is characteristic of thyroid cancer in this age group and not a result of radiation. It was also concluded that potential preventive therapy with L-thyroxine on a broad scale is not indicated at this time.