IMPACT OF CALCIUM CHANNEL BLOCKER THERAPY IN PATIENTS WITH MICROVASCULAR ANGINA

我们之前已经报道了钙通道的症状益处。 微血管心绞痛患者的阻滞剂治疗(胸痛，正常 冠脉造影术、冠脉微血管收缩反应 麦角新碱)。为了评估钙通道阻滞剂的影响 在左心功能方面，我们使用了地尔硫卓、维拉帕米、 硝苯地平或尼卡地平治疗14例血压正常、休息异常的患者 和/或锻炼左心功能(根据所有 药物)进行放射性核素血管造影术，并在3周后重复研究 几个月的钙通道阻滞剂。钙通道阻滞剂治疗 与全球和区域左翼的显著改善相关 运动时的脑室反应。我们得出结论，钙通道 阻滞剂改善微血管患者的左心功能 心绞痛和诱发心肌缺血的证据，可能是通过 改善运动应激时冠脉血流动力学。

We have previously reported the symptom benefit of calcium channel blocker therapy in patients with microvascular angina (chest pain, normal coronary angiograms, coronary microvascular constrictor response to ergonovine). In order to assess the impact of calcium channel blockers on left ventricular function, we administered diltiazem, verapamil, nifedipine, or nicardipine to 14 normotensive patients with abnormal rest and/or exercise left ventricular function (as assessed off all medications) by radionuclide angiography, and repeated studies after 3 months of calcium channel blockers. Calcium channel blocker therapy was associated with significant improvement in global and regional left ventricular responses to exercise. We conclude that calcium channel blockers benefit left ventricular function of patients with microvascular angina and evidence for inducible myocardial ischemia, probably by improving coronary flow dynamics during exercise stress.