"FALSE POSITIVE" RADIONUCLIDE ANGIOGRAPHIC STUDIES IN WOMEN WITH CHEST PAIN

女性胸痛的“假阳性”放射性核素血管造影研究

• 批准号: 3843397
• 负责人: R O CANNON
• 金额: --
• 依托单位: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3843397
• 关键词: angina pectoris; angiography; coronary artery; coronary disorder; electroencephalography; exercise; female; heart function; heart ventricle; human middle age (35-64); human subject; myocardial ischemia /hypoxia; noninvasive diagnosis; nuclear medicine; radionuclide diagnosis; stress

Women with chest pain who undergo noninvasive testing in order to determine etiology of their pain are found to have a high incidence of "false positive" responses, i.e., results suggestive of inducible myocardial ischemia in the absence of angiographic evidence of coronary artery disease. In order to assess the significance of "false positive" noninvasive testing in women with chest pain and normal coronary angiograms, 26 women < 60 years of age with chest pain, normal coronary angiograms and normal resting left ventricular function underwent radionuclide angiographic assessment of left ventricular function during graded supine bicycle ergometry and exercise thallium scintigraphy using the Standard Bruce Protocol. Nine women had abnormal exercise left ventricular function (left ventricular ejection fraction decreased or wall motion abnormalities were detected during exercise) and 17 women had normal exercise left ventricular function. Six of 9 (67%) women with abnormal exercise left ventricular function had reversible defects by thallium scintigraphy, compared to only 1 of 17 (6%) women with normal exercise left ventricular function (p<0.003). There was no correlation between the exercise EKG or fixed thallium defects and exercise left ventricular function. Thus, abnormal left ventricular functional responses to exercise in women with chest pain and normal coronary angiograms are commonly associated with evidence of abnormal myocardial perfusion, most likely representing abnormal coronary microvascular function during stress.

患有胸痛的女性接受非侵入性检查，以便

项目成果

Leukocyte-suppressing influences of interleukin (IL)-10 in cardiac allografts: insights from IL-10 knockout mice.

白细胞介素 (IL)-10 对心脏同种异体移植物的白细胞抑制影响：来自 IL-10 敲除小鼠的见解。

• DOI: 10.1016/s0002-9440(10)65737-9
• 发表时间: 1998
• 期刊: The American journal of pathology
• 作者: Räisänen-Sokolowski,A;Glysing-Jensen,T;Russell,ME
• 通讯作者: Russell,ME