A RESOURCE FOR BIOMEDICAL MASS SPECTROMETRY

华盛顿大学质谱学的这一研究应用 资源计划： 1)继续提供范围广泛的低分辨率GCMS和高分辨率GCMS 向生物医学研究人员提供分辨率质谱学服务 请求这项协助。 2)继续提供专家技术援助、分析服务、 对高精度GCMS选择离子监测的解释建议 底物含量的定量和稳定同位素的浓缩 生理样本。 3)提供同位素比值质谱学(IRMS)服务 氢、碳、氮、氧同位素的测定 内源底物代谢产物作为稳定的结果出现 人体内的同位素示踪实验。 4)提供高度稀释碳的GC/燃烧/IRMS分析 人类前体产物示踪剂中的同位素富集值 促进将这些研究应用于临床研究的研究 具有生物医学重要性的问题。 5)为生化底物提供LC MS、CF-FAB和SCF-MS服务 不适用于GCMS分析。 6)提供快速原子轰击和等离子体解吸电离质量 用于分析高分子量生物聚合物的光谱分析。 7)使这些设施可供合格的调查人员使用 在地方、区域、国家和国际各级。

This research application of the Washington University Mass Spectrometry Resource plans: 1) To continue to provide a wide range of low resolution GCMS, and high resolution mass spectrometry services to biomedical investigators who request this assistance. 2) To continue to provide expert technical assistance, analytical services, and interpretive advice on high precision GCMS selected ion monitoring quantitation of substrate content and stable isotope enrichment in physiological samples. 3) To provide isotope ratio mass spectrometry (IRMS) services for precise measurement of hydrogen, carbon, nitrogen, and oxygen isotopes in end products of endogenous substrate metabolism occurring as a result of stable isotope tracer experiments in man. 4) To provide GC/Combusion/IRMS analyses of the highly diluted carbon isotopic enrichment values occurring in human precursor-product tracer studies to facilitate application of these studies to clinical research problems of biomedical importance. 5) To provide LCMS, CF-FAB and SCF-MS services for biochemical substrates not amenable to GCMS analysis. 6) To provide fast atom bombardment and plasma desorption ionization mass spectrometry for analysis of biopolymers of high molecular weight. 7) To make these facilities available for use by qualified investigators at the loca, regional, national and international levels.