Cytokine signalling and the regulation of normal and leukaemic blood cells

白细胞的形成和活动是由称为细胞因子的蛋白质信使调节的。细胞因子通过诱导信号通路的激活来传递信息，这些信号通路协调细胞对感染的反应，但当这些反应过于强烈或在不适当的时间发生时，它们可能导致自身免疫性疾病、组织损伤和血癌。我们研究这些过程的自然反馈抑制剂，以便为这些疾病设计新的治疗方法。

The formation and actions of white blood cells are regulated by protein messengers called cytokines. Cytokines deliver their message by inducing the activation of signalling pathways that orchestrate the cell’s response to infection but when these responses occur too robustly or at inappropriate times they can lead to autoimmune disease, tissue damage and blood cancers. We study the naturally occurring feedback inhibitors of these processes in order to devise new treatments for these diseases.