DEVELOPING OF ULTRASONIC TISSUE CHARACTERIZATION METHODS

该项目旨在提高超声成像的能力，以 检测并确定肿瘤的特征。之所以选择这个地区，是因为 超声成像在几乎所有专业中的广泛使用和 医疗环境。我们寻求的改进，选择做出的改进 超声波成像甚至更有用，因此会对 医疗实践。他们将通过改进为肿瘤学做出贡献 检测、诊断和治疗监测。 该计划由三个项目组成，它们采取不同的方法来 收集和处理数据以形成图像的问题。这些 项目基于新的方法以及对 在工业无损检测中取得成功的方法 在光学方面。我们的计划也以实验室和临床核心为基础 确保项目和项目之间的互动和协调 影像方式(US、CT和MRI)与病理之间的关系。这个结构 应该可以消除在以下情况下遇到的许多问题 试图通过以下途径改善超声组织定征 个人研究项目。此外，临床合作者将 受益于拥有各种成像方法，以 针对不同的目的进行评估。与其他人的相互比较 因此，可以有效地处理模式。 一个项目将收集动物和人类体内关于超声波的数据 组织和肿瘤的性质。这些数据将用于评估 正在开发的临床使用的定量方法的准确性。 另一个项目将评估经常被忽视的 组织特性的各向异性对目前和未来成像方法的影响，如 我们将寻求利用这种效应来表征组织。 以确保该计划作为超声方法学保持最新 在赠款期限内，我们已将相关工作包括在内 区域。某些类型的造影剂很有可能被广泛应用于 不久的将来。因此，我们已经包括了一个将开发的项目 一种很有前途的新造影剂。这个项目将使我们获得 具有表征这些材料的经验，并提供有关 使用对比度来增强与肿瘤相关的图像特征。 病人的安全问题不能被忽视。换能器和 测量系统项目已包括在内，因此我们将能够 改进我们的超声波剂量测量方法。该项目也将发展 用于准确采集宽带数据的传感器 建模，对于开发新方法是必不可少的，而且频率很高 用于皮肤和腔内新区域的换能器

This program project seeks to enhance the ability of ultrasonic imaging to detect and characterize tumors. This area was chosen because of the widespread use of ultrasonic imaging in practically all specialties and medical environments. The improvements that we seek, selected to make ultrasonic imaging even more useful, would thus have a large impact on medical practice. They would contribute to oncology through improved detection, diagnosis and treatment monitoring. The program consists of three projects that take different approaches to the problem of collecting and processing data to form images. These projects are based on new approaches as well as on adaptations of approaches that have been successful in industrial non-destructive testing and in optics. Our program is also based on laboratory and clinical cores for assuring interaction and co-ordination between the projects and between imaging modalities (US, CT and MRI) and pathology. This structure should remove many of the problems that have been encountered when attempting to improve the ultrasonic tissue characterization through individual research projects. Also, the clinical collaborators will benefit from having available a variety of image formation methods to evaluate for different purposes. The inter-comparison with other modalities can thus be efficiently handled. One project will gather animal and human in-vivo data on the ultrasonic properties of tissues and tumors. These data will be used to assess the accuracy of the quantitative methods being developed for clinical use. Another project will be assessing the often neglected effects of anisotropy in tissue properties on present and future imaging methods, as well seek to use such effects to characterize tissues. To assure that this program remains current as ultrasonic methodology advances during the term of the grant we have included work in related areas. Some type of contrast agent will most likely be widely used in the near future. Therefore we have included a project that will be developing a promising new contrast agent. This project will allow us to gain experience with characterizing these materials and offer guidance on the use of contrast in enhancing image features associated with tumors. Questions of patient safety must not be ignored. A transducer and measurement system project has been included so that we will be able to refine our ultrasonic dosimetry methods. This project also will develop transducers for wideband data collection that is needed for accurate modeling, essential for developing new methods, and high frequency transducers for the new areas of skin and intraluminal