PNEUMOCYSTIS CARINII BY INDUCED SPUTUM IN IMMUNOSUPPRESSED CHILDREN

患有HIV感染和其他免疫抑制疾病的儿科患者 容易患上卡氏肺孢子虫肺炎。 支气管镜检查伴 支气管肺泡灌洗在技术上可能更难进行， 儿科患者。 因此，一种替代的诊断方法， 是否安全可靠 根据我们的成人数据， 该痰诱导已被证明是一种安全且高度敏感的 我们已经进行了一项前瞻性的评估， 痰液诱导对小儿卡氏肺孢子虫肺炎的诊断价值 一 使用高渗氯化钠的类似超声雾化技术 无论是咳痰，口咽或鼻咽吸痰， 被雇用。 数据表明，卡氏肺孢子虫可以可靠地诊断， 这种技术在一岁的孩子身上。 这项技术是一种非常 安全有效地替代儿童支气管镜检查。 初始数据 发表在《儿科学杂志》上。 该项目 正在进行，一个主要目标是进一步改善采样技术， 以提高灵敏度。

Pediatric patients with HIV infection and other immunosuppressive disorders are susceptible to Pneumocystis carinii pneumonia. Bronchoscopy with bronchoalveolar lavage may be technically more difficult to perform in pediatric patients. Because of this, an alterative diagnostic method which was safe and reliable had to be determined. Based on our adult data in which sputum induction has been shown to be a safe and highly sensitive procedure, we have undertaken a prospective assessment of the utility of sputum induction for the diagnosis of P. carinii pneumonia in children. A similar ultrasonic nebulization technique using hypertonic sodium chloride with either expectoration, oropharyngeal or nasopharyngeal suctioning has been employed. Data indicate that P. carinii can be reliably diagnosed by this technique in children as young as one year. The technique is a very safe and effective alternative to bronchoscopy for children. Initial data from this study have appeared in the Journal of Pediatrics. The project is ongoing, and a major goal is to further improve the sampling technique in order to increase sensitivity.