MONKEY MODEL FOR AIDS

人类免疫缺陷病毒（HIV-1）在人类中引起艾滋病。 SIV在亚洲猴子中诱导类似艾滋病的疾病。 的 HIV-1感染和疾病动物模型系统的建立 对艾滋病疫苗研究和干预至关重要。 目前 只有黑猩猩可以感染HIV-1; 但不会产生疾病。 由于巨大的成本， 维持一只黑猩猩的生命，这不可能是一种疾病 一个更好的模式被发现了。 根据最近的一份报告， 华盛顿灵长类研究中心，我们进行了研究， 猪尾猴的HIV-1感染最初，我们正在测试 不同HIV-1分离株对猪尾型外周血淋巴细胞的体外感染性 包括田间分离株（< 4代）以及一些实验室- 适应性菌株 由于大多数北美的HIV-1分离株 在env区的V3环中是“MN”样的，我们的目标是接种疫苗 并显示出对“MN”样HIV-1分离株的保护作用。

The human immunodeficiency virus (HIV-1) causes AIDS in man. Its simian counterpart (SIV) induces an AIDS-like disease in Asian monkeys. The development of an animal model system for infection and disease by HIV-1 is essential for AIDS vaccine studies and intervention. Currently, the only animal species which can be infected by HIV-1 is the chimpanzee; however, no disease is produced. Due to the enormous cost of maintaining a chimpanzee and the fact that this cannot be a disease model, a better model was sought. Based upon a recent report from the Washington Primate Research Center, we undertook studies to investigate HIV-1 infection in pig-tail monkeys. Initially, we are testing infectivity of pig-tail PBLs in vitro using various HIV-1 isolates including field isolates (< 4 passages) as well as some laboratory- adapted strains. Since the majority of North American HIV-1 isolates are "MN"-like in the V3 loop of the env region, our aim is to vaccinate and demonstrate protection against an "MN"-like HIV-1 isolate.