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RESTRICTION FRAGMENT LENGTH POLYMORPHISMS IN NORMAL AND NEOPLASTIC TISSUES

RESTRICTION FRAGMENT LENGTH POLYMORPHISMS IN NORMAL AND NEOPLASTIC TISSUES
正常和肿瘤组织中的限制性片段长度多态性
批准号：
3808537
负责人：
B ZBAR
金额：
$0.0万
依托单位：
DIVISION OF CANCER BIOLOGY AND DIAGNOSIS
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/3808537
关键词：
cardiovascular neoplasm chromosome walking genetic library genetic mapping genetic markers head /neck neoplasm human genetic material tag human population genetics human subject human tissue linkage mapping molecular cloning neoplasm /cancer genetics nucleic acid probes restriction fragment length polymorphism restriction mapping retina disorder small cell lung cancer squamous cell carcinoma

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中文摘要
翻译
研究工作的主要目标是精确定位冯 Hippel-Lindau病基因 我们实验室以前的研究 表明VHL位于RAF 1和RAF 2之间的6-8 cM间隔内， D3S18。 D3 S601是我们鉴定的与VHL基因最接近的标记; 它位于紧邻VHL基因周围的区域。 我们有 分离的YAC克隆的所有标记接近VHL基因座，并在 通过基于YAC的染色体步移克隆该区域的过程。 43个探针在小细胞肺癌中的同源性缺失 线被识别。 人头部鳞状细胞癌和 颈部的特征是基因座上的等位基因丢失 染色体3 p。
英文摘要
The major goal of the research effort was to precisely locate the von Hippel-Lindau disease gene. Previous studies from our laboratory indicated that VHL is located in a 6-8 cM interval between RAF1 and D3Sl8. D3S601 is the closest marker we have identified to the VHL gene; it is located in a region immediately surrounding the VHL gene. We have isolated YAC clones for all markers close to the VHL locus and are in the process of cloning the region by YAC-based chromosome walking. Forty-three probes homozygously deleted in a small cell lung carcinoma line were identified. Human squamous cell carcinomas of the head and neck were shown to be characterized by a loss of alleles at loci on chromosome 3p.
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RESTRICTION FRAGMENT LENGTH POLYMORPHISMS IN NORMAL AND NEOPLASTIC TISSUES
RESTRICTION FRAGMENT LENGTH POLYMORPHISMS IN NORMAL AND NEOPLASTIC TISSUES
RESTRICTION FRAGMENT LENGTH POLYMORPHISMS IN NORMAL AND NEOPLASTIC TISSUES
RESTRICTION FRAGMENT LENGTH POLYMORPHISMS IN NORMAL AND NEOPLASTIC HUMAN TISSUES
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