DIAGNOSIS OF PNEUMOCYSTIS CARINII BY INDUCED SPUTUM IN IMMUNOSUPPRESSED CHILDREN

患有艾滋病和其他免疫抑制疾病的儿科患者 易患卡氏肺孢子虫肺炎。支气管镜检查伴 支气管肺泡灌洗在技术上可能更难进行， 儿科患者，可能与更多的发病率。因为 因此，必须有一种安全可靠的替代诊断方法， 被确定。根据我们的成人数据，其中痰诱导已经 被证明是一种安全和高度敏感的程序，我们已经采取了 前瞻性评估痰诱导的效用， 小儿卡氏肺孢子虫肺炎的诊断类似的超声波 使用高渗盐水的雾化技术， 已经采用口咽或鼻咽喉抽吸。数据 表明卡氏肺孢子虫可以通过该技术可靠地诊断， 一岁的孩子。该技术是一种非常安全有效的 儿童支气管镜检查的替代方法。本研究的初始数据 发表在《儿科学杂志》上该项目正在进行中，A 主要目标是改进取样技术， 灵敏度

Pediatric patients with AIDS and other immunosuppressive disorders are susceptible to Pneumocystis.carinii pneumonia. Bronchoscopy with bronchoalveolar lavage may be technically more difficult to perform in pediatric patients and may be associated with more morbidity. Because of this, an alterative diagnostic method which was safe and reliable had to be determined. Based on our adult data in which sputum induction has been shown to be a safe and highly sensitive procedure, we have undertaken a prospective assessment of the utility of sputum induction for the diagnosis of P. carinii pneumonia in children. A similar ultrasonic nebulization technique using hypertonic saline with either expectoration, oropharyngeal or nasopharangeal suctioning has been employed. Data indicates that P. carinii can be reliably diagnosed by this technique in children as young as one year. The technique is a very safe and effective alternative to bronchoscopy for children. Initial data from this study have appeared in the Journal of Pediatrics. The project is ongoing, and a major goal is to improve the sampling technique in order to increase sensitivity.