THE ANALYTICAL CHEMISTRY OF ANTI-AIDS AGENTS

本项目的目标是研究和开发适用于 分析方法：(1)建立势的结构和纯度 抗艾滋病药物和新型抗病毒药物，(2)测定物理、化学 和生化性质，包括辛醇-水分配系数 这些化合物及其代谢物，以及(3)测量这些药物和 生物样品中的代谢物，以阐明药理和 测定药代动力学。高效液-质联用技术 光谱分析是强调的技术。目前感兴趣的化合物有 二脱氧核苷包括DDG，6-卤代-dd-嘌呤。 2-NH(2)-6-卤代-dd-嘌呤，2‘-F-dd-ara-A，2’-F-dd-ara-I， 2‘-F-dd-Ara-G、2’-F-dd-C、2‘-F-dd-Ara-C和6-取代-2’-F-dd-嘌呤。

The objective of this project is the research and development of suitable analytical methods to: (1) establish the structure and purity of potential anti-AIDS agents and new antiviral drugs, (2) determine physical, chemical and biochemical properties, including octanol-water partition coefficients , of these compounds and their metabolites, and (3) measure these drugs and their metabolites in biological samples to elucidate pharmacology and to determine pharmacokinetics. High-performance liquid chromatography and mass spectrometry are emphasized techniques. Compounds of current interest are dideoxynucleosides including ddG, 6-halo-dd-Purines. 2-NH(2)-6-halo-dd-Purines, 2'-F-dd-ara-A, 2'-F-dd-ara-I, 2'-F-dd-ara-G,2'-F-dd-C, 2'-F-dd-ara-C and 6-substituted-2'-F-dd-Purines.