EPIDEMIOLOGY OF CUTANEOUS CANCERS--A MODEL FOR HUMAN CARCINOGENESIS

皮肤癌的三项协作性人群研究是 将重点放在紫外线、饮食因素、 生化标记物和其他已知或可疑的流行病学 风险因素及其相互关系。病例和控制将 从亚利桑那州东南部的6个县获得。二 建议的研究将采用病例对照设计，病例数为 由病理确诊的皮肤疾病定义 一项研究和确定病例的基底细胞癌或鳞状细胞癌 经病理证实的黑色素瘤诊断为 第二项研究。对于每一种情况，从人口中选出2人 这些县的年龄、性别、种族血统和 地理区域，将被选为使用随机数字的控件 正在拨号。由于年龄和性别分布相似， 黑色素瘤和非黑色素瘤(即基底细胞和鳞状细胞 癌症)病例中，很大比例的人被选为 一项研究的对照预计将被匹配并用作 第二个病例对照研究。 第三项拟议研究将使用前瞻性队列设计和 包括第一个病例中包括的所有非黑色素瘤病例- 上述对照研究加上具有1个或1个以上的受试者 有非黑色素瘤皮肤癌的病史。队列受试者将会有 他们的非黑色素瘤皮肤癌经病理证实 完全切除，并将被跟踪诊断为 随后的皮肤癌。 所有受试者都将在学习期间接受采访。 非黑色素瘤受试者也将在12个月后接受采访。 间隔时间。血液和组织样本将被收集， 在学习时为所有研究对象处理和存储。 这些标本将保存起来，以便在1989年期间进行分析- 90(这个项目的第四年)，在采访之后，数据已经 分析过了。样本的分析将包括视黄酸棕榈酸酯， 分析确定的β-胡萝卜素和其他微量营养素 在访谈过程中获得的饮食摄入量数据。A四年 所有研究的总持续时间是有计划的，包括分析和 手稿的准备。

Three collaborative population based studies of skin cancer are proposed which will focus upon ultraviolet light, dietary factors, biochemical markers and other known or suspected epidemiologic risk factors and their interrelationship. Cases and controls will be obtained from the 6 counties of Southeastern Arizona. Two of the proposed studies will use a case-control design, with cases defined by a pathologically confirmed diagnosis of cutaneous basal or squamous cell carcinoma for one study and cases defined by a pathologically confirmed diagnosis of melanoma for the second study. For each case, 2 persons from the population of these counties, frequency matched by age, sex, ethnic origin, and geographic region, will be selected as controls using random digit dialing. Due to the similar age and sex distribution for melanoma and nonmelanoma (i.e. basal and squamous cell carcinoma) cases, a large proportion of persons selected as controls for one study are anticipated to be matched and used as controls for the second case-control study. The third proposed study will use a prospective cohort design and include all cases of nonmelanoma included in the first case- control study described above plus added subjects with 1 or more prior nonmelanoma skin cancers. Cohort subjects will have had their nonmelanoma skin cancer pathologically confirmed completely removed and will be followed for the diagnosis of subsequent skin cancers. All subjects will be interviewed at the time on study. Nonmelanoma subjects will also be interviewed at 12 month intervals. Blood and tissue specimens will be collected, processed and stored for all study subjects at the time on study. These specimens will be kept in storage for analysis during 1989- 90 (year 4 of this project) and after the interview, data has been analyzed. Analyses of specimens will include retinyl palmitate, beta-carotene and other micronutrients identified from analysis of dietary intake data obtained during interview. A four year total duration for all studies is planned and includes analysis and preparation of manuscripts.