Deciphering the overlapping roles of SSB1 and SSB2 in the regulation of haematopoiesis and intestinal homeostasis

我们的工作重点是阐明两种新发现的相关单链DNA结合蛋白（Ssb1和Ssb2）在血液和肠道系统发育中的作用。当两个基因都被删除时，小鼠由于骨髓衰竭和肠道萎缩而在8天后死亡。我们的双敲除模型与辐射损伤对血液和肠道系统的影响相似。对这些系统的毒性是提供抗肿瘤治疗的重大障碍。

Our work centres on elucidating the role of two newly identified and related single-stranded DNA binding protein (Ssb1 and Ssb2) in development of blood and gut system. When both genes are deleted mice die with 8 days of knockdown due to bone marrow failure and intestinal atrophy. Our double knockout model parallels the consequences of radiation damage on blood and gut system. Toxicity to these systems is a significant hindrance in delivering anti-tumor therapy.