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HIGH DOSE METHOTREXATE WITH LEUCOVORIN RESCUE IN RHEUMATOID ARTHRITIS

HIGH DOSE METHOTREXATE WITH LEUCOVORIN RESCUE IN RHEUMATOID ARTHRITIS
高剂量甲氨蝶呤联合亚叶酸拯救类风湿性关节炎
批准号：
3822946
负责人：
J H KLIPPEL
金额：
$0.0万
依托单位：
NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/3822946
关键词：
combination chemotherapy dosage drug administration routes drug adverse effect histocompatibility antigens human subject human therapy evaluation intravenous administration leucovorin leukocyte activation /transformation lymphocyte methotrexate rheumatoid arthritis skeletal disorder chemotherapy

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中文摘要
翻译
5例重症，治疗难治性类风湿
英文摘要
Five patients with severe, treatment refractory rheumatoid arthritis were treated with high dose intravenous methotrexate (500mg/m2) followed by leucovorin (50 mg/m2). Four courses of chemotherapy were given over a 2 month interval. At the end of the final course, there are a 50% or greater improvement in joint swelling and pain indices and morning stiffness in all patients. Clinical responses persisted for 6 to 14 weeks post therapy. High dose methotrexate-leucovorin was associated with a significant reduction in DR antigen expression on peripheral Leu 2, Leu 3 and Leu 4 lymphocytes.
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CLINICAL AND THERAPEUTIC STUDIES OF THE RHEUMATIC DISEASES
CLINICAL AND THERAPEUTIC STUDIES OF THE RHEUMATIC DISEASES
CLINICAL AND THERAPEUTIC STUDIES OF THE RHEUMATIC DISEASES
CLINICAL AND THERAPEUTIC STUDIES OF THE RHEUMATIC DISEASES
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