ROLES OF DNA DEMETHYLATION AND CYTOTOXIC EFFECT IN HIV EXPRESSION

人类免疫缺陷病毒型的一个显著临床特征是 1（HIV-1）感染的潜伏期相对较长， 其特征在于病毒的低至不可检测的表达， 病毒血症感染的早期急性期。 然而，机制 负责维持这种临床潜伏期的人至今还没有 不太了解。 在延长的潜伏期或无症状期， 在外周血中仅检测到少数感染细胞。 这可能是 这是由于宿主的细胞能够有效地清除表达HIV-1的细胞， 感染早期的免疫防御机制。 然而， 抑制病毒表达的未鉴定的机制可 在感染的早期阶段， 感染

One of the salient clinical features of human immunodeficiency virus type 1 (HIV-1) infection is the relatively long period of latency which is characterized by a low to undetectable expression of the virus, following an early acute phase of infection with viremia. However, the mechanisms responsible for the maintenance of this clinical latency have been as yet poorly understood. During the extended latency or asymptomatic period, only a few infected cells are detected in peripheral blood. This may be due to an efficient removal of HIV-1-expressing cells by the host's immune defense mechanisms at early stages of infection. However, yet unidentified mechanism(s) to suppress the expression of the virus may also be operative in infected individuals at the early stages of infection.