RENAL LESIONS IN THE ABLATION MODEL

大鼠肾次全切除术，5/6 th消融模型，导致 肾功能进行性丧失和慢性肾衰竭。 我们 假设进行性肾小球病变是由于早期的 肾小球驻留细胞周转增加。 这导致 肾小球生长异常，肾小球体积增加 其可使用形态测量法检测。 我们已执行 放射自显影研究，使用3 H-胸苷，发现在两个 在肾大部切除术后的10天内， 肾小球细胞有丝分裂指数以及 动脉壁的细胞 这些发现表明， 是肾小球硬化症发展的早期事件 减少肾脏质量。

Subtotal nephrectomy in rats, the 5/6ths ablation model, leads to progressive loss of kidney function and chronic renal failure. We postulated that the progressive glomerular lesions were due to an early increase in the turnover of glomerular resident cells. This leads to abnormal glomerular growth, with an increase in the glomerular volume which was detectable using morphometric measurements. We have performed autoradiographic studies, using 3H-thymidine, and found that within two days following subtotal nephrectomy there was an increase in the glomerular cell mitotic index, as well as an increase in the turnover of the cells in the arterial wall. These findings suggest that dysregulation of cell growth is an early event in the development of glomerulosclerosis following reduction in renal mass.