THE ROLE OF SUBCLINICAL INFECTION AND CYTOKINES IN PRETERM PARTURITION

该项目的目标是定义提升的角色 宫内感染在早产和分娩的病因中的作用 阐明早产信号的细胞和分子机制 在感染的背景下分娩，并将这一知识应用于 改进早产的诊断和治疗方法。 临床研究的重点是确定频率和 羊膜腔微生物侵袭的临床意义 早产、早产、胎膜早破患者， 宫颈功能不全，足月正常分娩。我们已经建立了 不同快速实验室检测方法在临床应用中的价值和局限性 羊膜腔微生物侵袭的诊断 对早产的预测。 实验室研究主要集中在巨噬细胞的研究上。 细胞因子(白介素1、肿瘤坏死因子、白介素6)对血管内皮细胞的影响 人类分娩与感染相关的机制， 宫内上升性感染动物模型的建立 抗细胞因子药物(天然白介素I)作用的研究 受体拮抗剂和肿瘤坏死因子拮抗剂)预防 感染导致早产。

The objectives of this project are to define the role of ascending intrauterine infection in the etiology of preterm labor and delivery, to elucidate the cellular and molecular mechanisms signalling preterm parturition in the setting of infection and to apply this knowledge to improve the diagnostic and therapeutic approach to preterm labor. Clinical investigation has focused on determining the frequency and clinical significance of microbial invasion of the amniotic cavity in patients with preterm labor, preterm premature rupture of membranes, cervical incompetence and normal labor at term. We have established the value and limitations of different rapid laboratory tests in the diagnosis of microbial invasion of the amniotic cavity and in the prediction of preterm delivery. Laboratory investigation has focused on the study of macrophage cytokines (interleukin-1, tumor necrosis factor, interleukin-6) on the mechanisms of human parturition associated with infection, the development of an animal model for ascending intrauterine infection and the study of the role of anticytokine agents (interleukin-I natural receptor antagonist and tumor necrosis factor antagonists) in preventing infection induced preterm delivery.