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TREATMENT OF OSTEOPOROSIS WITH DICLOFENAC SODIUM

TREATMENT OF OSTEOPOROSIS WITH DICLOFENAC SODIUM
双氯芬酸钠治疗骨质疏松症
批准号：
3851793
负责人：
NORMAN H. BELL
金额：
$0.0万
依托单位：
MEDICAL UNIVERSITY OF SOUTH CAROLINA
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/3851793
关键词：
antiinflammatory agents bone metabolism chemoprevention female human subject human therapy evaluation osteoporosis pathologic bone resorption postmenopause prostaglandin inhibitors skeletal disorder chemotherapy

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中文摘要
翻译
在实验室动物中进行的研究表明， 骨吸收和雌激素抑制前列腺素合成。 一个 开始研究以检验双氯芬酸钠， 非甾体抗炎药，将有助于预防 绝经后骨质流失 绝经前妇女的结果表明， 药物使绝经后妇女的尿钙减少20% 尿钙减少了40%
英文摘要
Studies in laboratory animals suggest that prostaglandins mediate ongoing bone resorption and that estrogen inhibits prostaglandin synthesis. An investigation was begun to test the hypothesis that diclofenac sodium, a nonsteroidal anti-inflammatory drug, would be useful in preventing postmenopausal bone loss. Results in premenopausal women indicate that the drug produced a 20% decrease in urinary calcium and in postmenopausal women a 40% decrease in urinary calcium.
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TREATMENT OF OSTEOPOROSIS WITH DICLOFENAC SODIUM
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