COLLABORATIVE PROJECTS IN ENVIRONMENTAL HEALTH SCIENCES

环境健康科学方面的合作项目包括 质谱工作组与其他机构合作的项目 团体，无论是内部和外部的研究所，以解决相互的问题， 兴趣 这些项目的主要重点是1）结构 确定未知结构的生物化合物，2） 生物学途径的鉴定和/或确认，以及3） 生物学结构测定策略的发展 重要的化合物。 目前正在研究的主要项目包括：1）确定 在气道上皮组织中存在白三烯B4; 2） 低分子量肝细胞生成素B结构测定 刺激肝细胞DNA合成的血清中， 被异生素化合物模仿的原型分子，例如 苯巴比妥，导致肝细胞肥大和增殖; 3） 感染细胞表达的小肽的结构测定 与流感病毒接触，导致细胞被T细胞识别为 感染（艾滋病毒感染模型）; 4）联合发展 用于鉴定自旋捕获自由基的LC/EPR/MS技术。 后一个项目涉及化学结构的确定， 产生的自由基和自由基作为中间体产生， 生物系统中的酶过程。

Collaborative projects in the environmental health sciences includes those projects in which the mass spectrometry work-group collaborates with other groups, both within and without the institute to solve problems of mutual interest. The major focuses of these projects are 1) the structure determination of biological compounds of unknown structure, 2) identification and/or confirmation of biological pathways and 3) development of strategies for the structure determination of biologically important compounds. Major projects currently under investigation include; 1) the identification of the presence of leukotriene B4 in airway epithelium tissues; 2) the structure determination of hepatopoietin B, a low molecular weight compound in serum that stimulates hepatocyte DNA synthesis and is hypothesized to be the prototype molecule mimicked by xenobiotic compounds, such as phenobarbital, that cause hepatocyte hypertrophy and proliferation; 3) the structure determination of the small peptides expressed by cells infected with flu virus that cause the cell to be recognized by T-cells as being infected (a model of HIV infection) and; 4) the development of combined LC/EPR/MS techniques for the identification of spin-trapped free radicals. This latter projects involves the structure determination of chemically produced free-radicals and of free-radicals produced as intermediates in enzymatic processes in biological systems.