A RESOURCE FOR BIOMEDICAL MASS SPECTROMETRY

本研究应用华盛顿大学质谱仪 资源计划： 1)继续提供广泛的低分辨率GCMS，以及高 为生物医学研究人员提供高分辨率质谱服务， 请求这种援助。 2)继续提供专家技术援助、分析服务， 高精度GCMS选择离子监测的解释性建议 基质含量和稳定同位素富集的定量 生理样本 3)提供同位素比质谱（IRMS）服务， 氢、碳、氮和氧同位素的测量 内源性底物代谢的产物是由于稳定的 人体同位素示踪实验 4)提供高稀释碳的GC/Combusion/IRMS分析 人类前体产物示踪剂中出现的同位素富集值 促进这些研究应用于临床研究的研究 生物医学的重要性。 5)提供生化底物的LCMS、CF-FAB和SCF-MS服务 不适合GCMS分析。 6)提供快速原子轰击和等离子体解吸电离质量 用于分析高分子量生物聚合物的光谱法。 7)使这些设施可供合格的研究者使用， 地方、区域、国家和国际各级。

This research application of the Washington University Mass Spectrometry Resource plans: 1) To continue to provide a wide range of low resolution GCMS, and high resolution mass spectrometry services to biomedical investigators who request this assistance. 2) To continue to provide expert technical assistance, analytical services, and interpretive advice on high precision GCMS selected ion monitoring quantitation of substrate content and stable isotope enrichment in physiological samples. 3) To provide isotope ratio mass spectrometry (IRMS) services for precise measurement of hydrogen, carbon, nitrogen, and oxygen isotopes in end products of endogenous substrate metabolism occurring as a result of stable isotope tracer experiments in man. 4) To provide GC/Combusion/IRMS analyses of the highly diluted carbon isotopic enrichment values occurring in human precursor-product tracer studies to facilitate application of these studies to clinical research problems of biomedical importance. 5) To provide LCMS, CF-FAB and SCF-MS services for biochemical substrates not amenable to GCMS analysis. 6) To provide fast atom bombardment and plasma desorption ionization mass spectrometry for analysis of biopolymers of high molecular weight. 7) To make these facilities available for use by qualified investigators at the loca, regional, national and international levels.