Defining genomic mechanisms associated with treatment response, drug resistance and early blast crisis in chronic myeloid leukaemia

慢性髓性白血病如果不治疗是一种致命的疾病。现在大多数病人在新药的帮助下存活了下来，但仍有一些病人很快死亡。我的目标是通过调查诊断时患者的基因组成来理解这些差异。有些人可能有基因突变，使药物无法有效发挥作用。基因突变检测技术可以同时搜索3万个以上的基因。这项工作可以通过寻找新的治疗靶点来提高更多患者的生存率。

Chronic myeloid leukaemia is a fatal disease if untreated. Most patients now survive with new drugs, but some still rapidly die. I aim to understand these differences by investigating the genetic makeup of patients at diagnosis. Some may have gene mutations that prevent drugs from working effectively. Mutations will be detected using technology that can search more than 30,000 genes at the same time. This work could lead to improved survival for more patients by finding new targets for therapy.