BRAIN TISSUE TRANSPLANTATION

这项研究主要是为了移植含有以下物质的组织 儿茶酚胺或L多巴(即肾上腺髓质，肿瘤细胞，遗传学上) 改变的细胞和胚胎脑组织)进入大脑。它的目的是 为了阐明移植后这些组织的特性，并 阐明宿主大脑对移植组织的反应。 具体地说，这些实验使用非灵长类动物模型来：(1) 发展脑组织移植的临床应用技术 帕金森氏症；(2)开发脑组织移植技术 这最终可能适用于其他疾病，如精神分裂症 和癫痫，如果和当这些疾病被充分理解到 允许这种应用；(3)开发替代细胞类型，例如 永生化神经元，用于脑内移植；以及(4)阐明 控制大脑发育的因素和大脑对损伤或 损害，特别是黑质纹状体多巴胺系统。 在过去一年的报告中，在这些方面取得了重大进展 区域。

The study is primarily aimed at transplanting tissues containing catecholamines or L-DOPA (i.e., adrenal medulla, tumor cell, genetically altered cell, and embryonic brain tissue) into the brain. Its purpose is to elucidate the properties of these tissues after transplantation and to elucidate the response of the host brain to the transplanted tissues. Specifically, these experiments employ nonprimate animal models to; (1) develop the techniques of brain tissue transplantation for clinical use in Parkinson's disease; (2) develop brain tissue transplantation techniques which eventually may be applicable to other disorders such as schizophrenia and epilepsy, if and when these disorders become sufficiently understood to permit such applications; (3) develop alternate cell types, such as immortalized neurons, for transplantation into the brain; and (4) elucidate the factors controlling brain development and brain response to injury or impairment, with particular emphasis on the nigrostriatal dopamine system. During the past reporting year, significant progress has been made in these areas.