Defining the machinery for mitochondrial turnover governed by the Parkinson’s Disease proteins PINK1 and Parkin

帕金森氏症是一种中枢神经系统的退行性疾病，其根本原因尚不清楚。为了更好地理解是什么出了问题，这项研究将调查PINK1和Parkin的功能，这两种蛋白质在这种疾病的遗传形式中发生突变，在维持细胞健康方面发挥重要作用。本研究结果将用于探索治疗帕金森病症状的新靶点。

Parkinson’s disease is a degenerative disorder of the central nervous system in which the underlying cause is mostly unknown. To pave the way to a better understanding of what goes wrong, this study will investigate the function of PINK1 and Parkin, two proteins that are mutated in inherited forms of the disease that play important roles in maintaining cellular health. The results of this study will be used in exploring new therapeutic targets for the treatment of Parkinson’s disease symptoms.