UPGRADE OF A 4 7T/40CM GE CSI INSTRUMENT

高磁场强度对于优化信号至 核磁共振中的噪声和光谱分辨率。为此，一个4.7T/40厘米口径GE 仪器是三年前购买的，用于基础研究 在各种动物模型上。然而，从那时起，核磁共振技术 技术也有了根本性的进步。目前的仪器是 过时，并限制了研究的范围和质量 被执行。几种技术，尤其是空间局部化的 光谱学，在目前的系统中是不可行的。 因此，该提案要求将该文书升级为 让它保持在核磁共振技术的前沿。两个主要的升级是 已请求。第一种是针对两组不同的屏蔽渐变 直径。这将极大地提高我们的空间表演能力 局域光谱学、核磁共振显微镜和高速成像 和小动物模型。第二次升级是为了购买一台新电脑 基于SUN计算机的控制台。目前的制度已经过时，而且 在脉冲序列编程方面非常严格，图 处方、实时参数优化、数据处理和 数据存储。 这些改进对于继续发展是必不可少的 用于各种研究的空间局域光谱和成像 JHMI的肿瘤学、心脏病学、放射学和神经学。

High magnetic field strengths are essential for optimized signal to noise and spectral resolution in NMR. To this end, a 4.7T/40cm bore GE instrument was purchased three years ago and is used for basic research on a variety of animal models. Since that time, however, NMR techniques and technology have radically improved. The present instrument is outdated, and restricts the scope and quality of the research that can be performed. Several techniques, especially spatially localized spectroscopy, are not feasible with the present system. Consequently this proposal requests an upgrade of this instrument to keep it at the cutting edge of NMR technology. Two major upgrades are requested. The first is for two sets of shielded gradients of differing diameters. This will greatly improve our ability to perform spatially localized spectroscopy, NMR microscopy and high speed imaging on large and small animal models. The second upgrade is for a new computer console based on a SUN computer. The present system is outdated and very restrictive with regards to pulse sequence programming, graphic prescription, real time parameter optimization, data processing, and data storage. These improvements are essential for the continued development of spatially localized spectroscopy and imaging for a variety of studies in oncology, cardiology, radiology and neurology at JHMI.