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GLYCOGEN STORAGE DISEASE AND THE EFFECT OF DICHLORACETATE IN TYPE IA GLYCOGENESIS

GLYCOGEN STORAGE DISEASE AND THE EFFECT OF DICHLORACETATE IN TYPE IA GLYCOGENESIS
糖原贮积症和二氯乙酸对 IA 型糖原生成的影响
批准号：
3878039
负责人：
J B SIDBURY
金额：
$0.0万
依托单位：
EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/3878039
关键词：
amylases child (0-11) dichloroacetate diet therapy food processing /preparation glucose 6 phosphatase glucose metabolism glycogen storage disease type I glycogen storage disease type III glycogen storage disease type IV human subject human therapy evaluation medical complication metabolism disorder chemotherapy nutrition related tag starch

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中文摘要
翻译
食用变性玉米淀粉的血糖反应
英文摘要
The glycemic response to the administration of modified corn starch and amylopectin-compared with the unmodified form has consistently shown a lesser glycemic response to the modified forms of glycogen. The accumulated evidence convincingly points to a beneficial effect on kidney function when the blood glucose level is maintained with corn starch. If long-term observations support this impression, corn starch therapy will have a significant long-term impact on prognosis of type I glycogen storage disease (GSD). This study is designed to determine the rate of glucose production by the liver in individuals with type I glycogenosis. Patients with type Ill GSD were studied as control GSD subjects. The calculations of the latest data is not yet complete. The pharmacokinetics and the effect of dichloracetate in patients with type Ia glycogenosis were studied in 3 patients.
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