Defining the role of the major subsets of renal mononuclear phogocytes

慢性肾脏病(CKD)是澳大利亚死亡和发病的主要原因，目前治疗选择有限。肾单核巨噬细胞(RMP)是重要的免疫细胞，在肾脏的健康和疾病中起着重要的作用。然而，RMP是一组异质细胞，在CKD的发展和进展中的作用尚不明确。我们将明确RMP的主要亚型在CKD中的作用，并探索它们在CKD治疗中的潜力。

Chronic Kidney Disease (CKD) is a major cause of death and morbidity in Australia, and currently therapeutic options are limited. Renal mononuclear phagocytes (rMP) are important immune cells which play a central role in health and disease of the kidney. However, rMP are a heterogenous group of cells with a poorly defined role in the development and progression of CKD. We will define the role of major subsets of rMP in CKD, and explore their potential for treating CKD.