Defining the role of zinc in human macrophage responses to Salmonella

据估计，世界人口的三分之一受到轻度至中度缺锌的影响，这使人们容易患一系列传染病。锌的免疫调节作用已被认识多年，事实上，锌补充剂被用于治疗严重的腹泻病。本项目旨在通过关注巨噬细胞（一种参与杀死入侵微生物的关键细胞类型）来了解锌的抗感染机制。

It is estimated that one third of the worlds population is affected by mild to moderate zinc deficiency, and that this predisposes to a range of infectious diseases. The immunomodulatory effects of zinc have been appreciated for many years, and indeed zinc supplementation is used to treat severe diarrhoeal diseases. This project aims to understand the anti-infective mechanisms of zinc by focusing on macrophages, a key cell type involved in killing invading microorganisms.