COMPUTED TOMOGRAPHIC SYSTEM FOR NEUROLOGIC RESEARCH

埃文斯顿医院的神经病学研究实验室在此申请 购买通用电气CT/T 8800计算机断层扫描仪 扫描仪 该系统将专门用作研究工具， 研究脑和全身肿瘤中的双向毛细血管运输， 研究导致脑损伤的状态的形成生理过程， 水肿，并研究其他神经系统疾病中的毛细血管运输 系统 该系统的主要用途是研究药物输送 脑肿瘤的过程（普遍认为是一个主要的限制 脑肿瘤治疗中的因素），使用我们拥有的技术， 已经在我们的实验室里开发出来了。 我们还将试图操纵 通过改变毛细血管传输特性的药物递送，特别是 血管活性胺 在系统性肿瘤的类别中，我们将集中 严重影响卵巢癌，并将执行相同类型的药物 交付研究和操作。 这两种癌症都是“理想的”， 因为在这两种疾病中，在病程的早期仍然局限于局部， 适合于局部形式的药物递送操作。 但在 此外，我们将研究多发性硬化症的毛细血管生理学， 中风，血脑屏障的破坏导致发病 和死亡率。 我们将开发新的测量方法 导致脑水肿的生理过程 在整个 这些研究，我们将坚持我们的哲学观点， 实验室：所有研究必须首先证明在动物中有效 在患者使用之前， 所提出的系统是一个翻新的CT扫描仪。 它将被用 专门用于研究，并将位于我们的实验室附近 在新的研究大楼里 这将使我们能够扩大新的初步 已经开发的定量放射自显影研究，首先 到可以在体内和随着时间的推移进行研究的大型动物模型，然后 最终应用于患者。

The Neurology Research Laboratories at Evanston Hospital herein apply for a grant to purchase a General Electric CT/T 8800 Computed Tomographic Scanner. This system will be used exclusively as a research instrument to study bidirectional capillary transport in brain and systemic tumors, to study the formative physiological processes in states causing cerebral edema, and to study capillary transport in other diseases of the nervous system. The principal use of this system is to study drug delivery processes in brain tumors (universally acknowledged to a major limiting factor in the treatment of brain tumors), using techniques that we have already developed in our laboratories. We will also attempt to manipulate drug delivery by changing capillary transport properties, especially with vasoactive amines. In the category of systemic tumors we will concentrate heavily upon ovarian cancer, and will perform the same types of drug delivery studies and manipulations. Both of these cancers are "ideal", since in both disease remains confined locally early in the course and is amenable to local forms of drug delivery manipulation. However, in addition, we will study capillary physiology in multiple sclerosis and stroke, where breakdown of the blood-brain barrier contributes to morbidity and mortality in these diseases. We will develop new methods for measuring the physiological processes contributing to cerebral edema. Throughout these studies we will adhere to a philosophical viewpoint of our laboratories: all studies must first be proven to be efficacious in animal models before they are used in patients. The proposed system is a reconditioned CT scanner. It will be used exclusively for research and will be located adjacent to our laboratories in a new research building. It will enable us to extend new preliminary studies which have been developed with quantitative autoradiography, first to large animal models which can be studied in vivo and over time, and then to eventual application in patients.