EFFECTS OF GAMMA-IRRADIATION ON CELLS AND THEIR CONSTITUENTS

某些水溶性的磺化酞菁是有效的。 杀死哺乳动物细胞的光敏剂似乎是 有希望替代血卟啉衍生物的研究 人类肿瘤的光动力疗法(PDT)。邮报- 以人红细胞的光照光溶血为例 一种膜损伤敏化研究的模型系统 各种磺化的酞菁。清道夫研究 色氨酸(能与单线态氧快速反应)和 甘露醇(能迅速与羟基自由基反应，但不能 与单线态氧)的主要作用一致 磺化敏化光溶血中的单线态氧 铝酞菁。类似的结果也出现在 V-病毒光敏杀伤细胞的初步实验 79个中国仓鼠细胞。超声波的化学效应是 正在调查与体温过高有关的问题(用于 与放射治疗相结合)和可能的影响 诊断和治疗应用。在…的过程中 瞬时空化，坍塌的空化气泡导致 非常高的温度(大于5000摄氏度)和 导致水分解为氢的压力 原子和羟基自由基。对于包含挥发性物质的解决方案 化合物，如醇，反应产物是那些 典型的燃烧过程(在破裂的气泡中)和 那些与电离辐射的影响相似的是由于 逃逸到主体中的氢原子和羟基自由基 溶液与溶质分子发生反应。在.的情况下 高温下形成的甲醇、甲基自由基 碳氧键的解离以及自由基的解离 由氢原子和羟基自由基反应形成的 用自旋捕捉和电子自旋检测 共鸣。在声化学中产生的自由基 核酸碱基、核苷、氨基酸和多肽 已经被自旋捕获所确认。

Certain water soluble sulfonated phthalocyanines are efficient photosensitizers for killing mammalian cells are appear to be promising candidates for replacing hematoporphyrin derivative in photodynamic therapy (PDT) of human tumors. The post- illumination photohemolysis of human red blood cells was used as a model system for studying membrane damage sensitized by various sulfonated phthalocyanines. Scavenger studies with tryptophan (which reacts rapidly with singlet oxygen) and mannitol (which reacts rapidly with hydroxyl radicals but not with singlet oxygen) are consistent with the predominant role of singlet oxygen in the photohemolysis sensitized by sulfonated aluminum phthalocyanine. Similar results have been obtained in preliminary experiments for the photosensitized cell killing of V- 79 Chinese hamster cells. The chemical effect of ultrasound are being investigated in relation to hyperthermia (used in combination with radiation therapy) and the possible effects of diagnostic and therapeutic applications. In the process of transient cavitation, the collapsing cavitation bubbles result in very high temperatures (greater than 5000 degrees C) and pressures which lead to the dissociation of water to hydrogen atoms and hydroxyl radicals. For solutions containing volatile compounds such as alcohols, the reaction products are those typical of combustion processes (in the collapsing bubbles) and those similar to the effects of ionizing radiation due to the hydrogen atoms and hydroxyl radicals which escape into the bulk of the solution to react with solute molecules. In the case of methanol, methyl radicals formed by the high temperature dissociation of the carbon-oxygen bond, as well as radicals formed by the reactions of hydrogen atoms and hydroxyl radicals with methanol were detected by spin trapping and electron spin resonance. The radicals produced in the sonochemistry of nucleic acid bases, nucleosides, amino acids and peptides have been identified by spin trapping.