TREATMENT OF MALIGNANT BRAIN TUMORS WITH INTERSTITIAL RADIOTHERAPY

高级别胶质瘤的中位生存期仍不到一年， 尽管进行了多种形式的治疗 治疗被认为是轶事。 这些肿瘤通常已经超出了一个完整的限制， 手术切除和常规外照射剂量 放射治疗受到周围正常大脑的限制 宽容 我们相信我们可以达到更高的辐射剂量 通过将放射性碘-125种子直接植入肿瘤 进入肿瘤床，辐射急剧下降， 正常的大脑周围。 希望这将实现一个很大的 更好的治疗比，特别是在低剂量给药时 rates.

Median survival of high-grade gliomas remains less than a year, despite multi-modality treatment. Cure is considered anecdotal. These tumors usually have extended beyond the limits of a complete surgical resection, and the dose of conventional external beam radiotherapy has been limited by surrounding normal brain tolerance. We believe that we can achieve a higher radiation dose to the tumor by placing radioactive seeds of Iodine-125 directly into the tumor bed, with a sharp fall-off of radiation to the surrounding normal brain. Hopefully this will achieve a much better therapeutic ratio, especially when delivered at low dose rates.