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ANALYSIS OF AN PROTO-ONCOGENE ENCODING A PUTATIVE GROWTH FACTOR RECEPTOR

ANALYSIS OF AN PROTO-ONCOGENE ENCODING A PUTATIVE GROWTH FACTOR RECEPTOR
编码假定生长因子受体的原癌基因的分析
批准号：
3916872
负责人：
S A AARONSON
金额：
$0.0万
依托单位：
DIVISION OF CANCER EPIDEMIOLOGY AND GENETICS
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/3916872
关键词：
DNA cytokine receptors gel electrophoresis growth factor receptors molecular cloning natural gene amplification neoplastic cell neoplastic transformation nucleic acid hybridization oncogenes platelet derived growth factor protein tyrosine kinase protooncogene sarcoma

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中文摘要
翻译
使用克隆的v-FMS或小鼠血小板衍生生长因子受体 以cDNA1为探针，我们已分离到与 原癌基因家族。一种新的可能的蛋白激酶受体基因 已被鉴定，并用克隆的方法进行了鉴定。它的主要特征 到目前为止，它的结构与酪氨酸激酶受体相似 克隆并分享了一种常见的半胱氨酸分布模式 出现在血小板衍生生长因子受体中。 和集落刺激因子(CSF-1)。这种新基因是 在几个人类肉瘤细胞中过表达，表明这一点 基因可能参与了某些肿瘤的发生发展过程。
英文摘要
Using cloned v-fms or mouse platelet-derived growth factor receptor cDNA as a probe, we have isolated genomic DNA clones homologous to the proto-oncogene family. A novel putative kinase receptor gene has been identified and characterized by cDNA cloning. Its primary structure is similar to that of tyrosine kinase receptors thus far cloned and share a common pattern of cystreine distribution which is seen in the receptors for platelet-derived growth factor (PDGF) and colony stimulating factor (CSF-1). This new gene is overexpressed in several human sarcoma cells, suggesting that this gene may be involved in the neoplastic process of some tumors.
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会议论文
THE USE OF EXPRESSION CLONING TECHNIQUE IN STUDYING HUMAN TUMOR CELLS
STRUCTURAL CHARACTERIZATION OF PUTATIVE GROWTH FACTOR RECEPTOR GENE C-ERB-2
FUNCTIONAL CHARACTERIZATION OF SECRETED FORM OF A VEGF RECEPTOR
TRANSFORMING GENES IN EXPERIMENTAL ONCOGENESIS AND HUMAN CANCER
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