ASYMMETRIC SYNTHESIS--STRUCTURE, STEREOCHEMISTRY AND NMR

针对其中一张照片的类似物， 反式甲基对- 硝基肉桂酸盐。 当将单体的溶液在室温下照射时， 这些抗体的存在， 是已经产生了抗体的那个。 单体的光异构化，主要的光化学反应 在没有抗体的情况下，受到了极大的抑制。 因此 抗体结合位点作为模板， 选择性地一个反应。 结构和绝对 （Z）（+）-2-溴环十一碳-2-烯基樟脑酸酯立体化学 化合物制备作为研究的一部分， 对溴苯甲酸酯的手性光学性质 酯与中环构型和构象 烯丙基酯，在X射线晶体学研究中确定。 在同一研究过程中，结构和绝对 还研究了（E）（-）-2-环癸烯基樟脑酸酯立体化学 由X射线晶体学确定。 作为我们不对称合成工作的一部分，我们开发了一个通用的 多环芳香醇的代谢物的拆分方法 多环芳烃 该方法用于制备 （+）-l-苊醇，一种用于分析几种 - 是的 樟脑甲酸酯的绝对立体化学 用X-射线晶体衍射法鉴定了醇的酯 study. β-甲基氨基丙氨酸（BMAA）的手性样品（报道的 神经毒素）和15 N标记的样品制备， 酶的分解 已报道的神经毒素的代谢 以及它的药理学正在研究博士。 Markey等人，NIMH（参见Z 01-MH-00279-05-LCS）。

Antibodies were raised against an analogue of one of the photo products (the head-to-head syn dimer) of trans methyl p- nitrocinnamate. When a solution of the monomer was irradiated in the presence of these antibodies, the product formed preferentially was the one against which antibodies had been raised. Photoisomerization of the monomer, the major photochemical reaction in the absence of antibodies, was greatly suppressed. Thus, the antibody combining site serves as a template for promoting selectively one reaction. The structure and absolute stereochemistry of (Z) (+)-2-bromocycloundec-2-enyl camphanate, a compound prepared as part of a study of the relationship between the chiroptical properties of the corresponding p-bromobenzoate esters and the configuration and conformation of medium-ring allylic esters, was determined in an X-ray crystallographic study. In the course of the same study, the structure and absolute stereochemistry of (E) (-)-2-cyclodecenyl camphanate was also determined by X-ray crystallography. As part of our work on asymmetric synthesis we developed a general method of resolving polycyclic aromatic alcohols, metabolites of polycyclic aromatic hydrocarbons. This method was used to prepare (+)-l-acenaphthenol, a substrate used to analyze several dehydrogenases. The absolute stereochemistry of the camphanate ester of the alcohol was elucidated by an X-ray crystallographic study. Chiral samples of beta-methylaminoalanine (BMAA) (a reported neurotoxin) and of an 15N labeled sample were prepared utilizing an enzymic resolution. The metabolism of the reported neurotoxin and as well as its pharmacology are being investigated by Dr. Markey et al. in NIMH (see Z01-MH-00279-05-LCS).