BRAIN TISSUE TRANSPLANTATION

这项研究的主要目的是移植儿茶酚胺- 含有组织，包括肾上腺髓质、肿瘤细胞和 胚胎脑组织，进入大脑。它的目的是 阐明移植后这些组织的特性以及 宿主大脑对移植组织的反应。 具体地说，这些实验使用了非灵长类动物模型 为(1)发展脑组织移植技术 帕金森、S病的临床应用；(2)脑组织发育 移植技术，以便它们最终可能适用于 其他障碍，如精神分裂症和e#iepsy，如果和何时 这些障碍变得足够清楚，以至于允许这样的 应用；以及(3)阐明控制 大脑的发育和对损伤或损伤的反应， 特别强调黑质纹状体的多巴胺系统。 在过去的报告年度中，取得了重大进展 在这些地区。

This study is primarily aimed at transplanting catecholamine- containing tissues, including adrenal medulla, tumor cells, and embryonic brain tissue, into the brain. Its purpose is to elucidate the properties of these tissues after transplantation and the response of the host brain to the transplanted tissues. Specifically, these experiments employ non-primate animal models to (1) develop the techniques of brain tissue transplantation for clinical use in Parkinson,s disease; (2) develop brain tissue transplantation techniques so they eventually may be applicable to other disorders, such as schizophrenia and e#ilepsy, if and when these disorders become well enough understood to permit such applications; and (3) elucidate factors that control the development and the responses of the brain to injury or impairment, with particular emphasis on the nigrostriatal dopamine system. During the past reporting year, significant progress has been made in these areas.