THE USE OF FACIAL COOLING TO IMPROVE THE CONDITION OF MENTALLY DEPRESSED PATIENTS

单相或双相情感障碍患者(抑郁症) 已经被证明夜间温度异常高。 我们推测，体温升高可能是 治疗抑郁症的几种变化，如甲状腺激素降低 分泌物。选择性快速眼动(REM)等程序 睡眠，完全剥夺睡眠，以及服用药物 因为三环类抗抑郁药似乎能降低大脑温度。 我们认为这些药物的抗抑郁作用与 它们降低大脑温度的能力。此外，直接或 间接降温大脑可能有抗抑郁作用。 我们将通过冷却面部来检验我们的假设，这将会冷却 大脑通过逆流与静脉血进行热交换。

Patients with unipolar or bipolar affective disorder (depression) have been shown to have abnormally high nighttime temperatures. We hypothesize that elevated body temperature may be responsible for several alterations in depression such as reduced thyropin secretion. Procedures such as selective rapid eye movement (REM) sleep, total sleep deprivation, and administration of drugs such as tricyclic antidepressants appear to reduce brain temperature. We believe the antidepressant effects of these agents are related to their capacity to reduce brain temperature. Further, direct or indirect cooling of the brain might have antidepressant effects. We will test our hypothesis by cooling the face, which will cool the brain through countercurrent heat exchange with venous blood.