NEUROTOLOGY CLINICAL RESEARCH CENTER

这些神经耳科临床研究中心的工作是由一个 一起工作了几年的相关调查人员。这个 中心专注于听力学、人类听觉和前庭功能、动物 听觉和前庭功能、形态(光和电子 显微镜)、听觉系统神经解剖学和细胞生物学--生物化学 它们与听觉和听觉障碍的病理生理学有关 均衡。这项临床和基础研究的多学科计划 重点关注以下目标：(1)开发和完善技术 儿童和成人听力障碍的评估，重点是 声反射、听性脑干反应和行为相关性 中枢性听觉障碍；(2)研究人类听神经动作电位 和听性脑干反应来加深我们对外周听觉的了解 生理学和开发电生理测试以量化和定位 听力损失；(3)评估部分消融术后的功能改变 前庭系统和系统的后续补偿--都是直接的 测量(电生理分析)和间接测量(度数 步态偏差)；(4)研究本体感觉和视觉输入 前庭系统增强引起的失衡；(5)形态评估 和细胞生物学--与功能异常有关的生化发现；(6) 从功能和神经解剖学角度研究声反射通路；(7) 前庭神经节超微结构变化的检测 迷路切除；以及(8)研究改变的电子显微镜表现 耳毒性药物在鸡胚胎发育模型中的诱导作用。 中心研究主题是神经耳科的基础研究及其临床应用。 相关的障碍。

These Neuro-Otology Clinical Research Center efforts are conducted by a team of interrelated investigators who have worked together for several years. The Center focuses upon audiology, human auditory and vestibular function, animal auditory and vestibular function, morphology (both light and electron microscopy), auditory system neuroanatomy, and cellular biology--biochemistry as they relate to the pathophysiology of disorders of the senses of hearing and equilibrium. This multidisciplinary program of both clinical and basic research focuses upon the following objectives: (1) to develop and refine techniques for assessment of auditory disorders in children and adults, with emphasis on acoustic reflex, auditory brainstem response and behavioral correlates of central auditory disorders; (2) to study human auditory nerve action potential and auditory brainstem response to further our knowledge of peripheral auditory physiology and to develop electrophysiologic tests to quantify and localize hearing loss; (3) to evaluate the functional alterations after partial ablation of the vestibular system and the system's subsequent compensation--both direct measurements (electrophysiological analyses) and indirect measurements (degree of gait deviation) are used; (4) to study proprioceptive and visual input enhancement of vestibular system induced imbalance; (5) to assess morphological and cell biology--biochemical findings related to functional abnormalities; (6) to study acoustic reflex pathway both functionally and neuroanatomically; (7) to determine ultrastructure alteration in the vestibular ganglion after labyrinthectomy; and (8) to study electron microscopic findings of changes induced by ototoxic agents in developing chick embryo model. The central research theme is the fundamental study of neuro-otology and its related disorders.