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SALIVARY GLAND SECRETORY MECHANISMS DURING NORMAL AND ALTERED FUNCTIONAL STATES

SALIVARY GLAND SECRETORY MECHANISMS DURING NORMAL AND ALTERED FUNCTIONAL STATES
正常和功能改变状态下的唾液腺分泌机制
批准号:
3939949
负责人:
B J BAUM
金额:
$0.0万
依托单位国家:
美国
项目类别:
财政年份:
--
资助国家:
美国
项目状态:
未结题
起止时间:
至

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中文摘要
翻译
口腔的健康是靠唾液分泌维持的。 唾液腺的主要功能是产生这些 复杂的流体。我们利用体外分散的细胞,并培养 唾液腺细胞以了解控制机制 唾液形成。我们把这些研究的重点放在自主神经上 神经递质对分泌事件及其相关蛋白的调节 信令机制。衰老的大鼠腮腺继续 可作为研究自主神经受体的有用模型 控制外分泌腺泡细胞的钙处理。在此期间 本报告所述期间,主要的具体研究领域 准备工作包括(1)机械方面和功能方面 细胞α-肾上腺素受体动员的相关因素 钙和(2)神经递质受体的特性- 克隆的大鼠涎腺导管中的偶联信号机制 上皮细胞系。
英文摘要
The health of the oral cavity is maintained by salivary secretions. The principal function of salivary glands is to produce these complex fluids. We utilize in vitro dispersed cells, and cultured cells of salivary glands to understand mechanisms controlling saliva formation. We have focused these studies on autonomic neurotransmitter regulation of secretory events and associated signalling mechanisms. The aging rat parotid gland continues to be employed as a useful model to study autonomic receptor control calcium handling in exocrine acinar cells. During this reporting period the major specific areas of study with these preparations include (1) mechanistic aspects and functional correlates of alpha-adrenoreceptor mobilization of cellular calcium and (2) characterization of neurotransmitter receptor- coupled signalling mechanisms in a cloned rat salivary ductal epithelial cell line.
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SALIVARY GLAND SECRETORY MECHANISMS DURING NORMAL AND ALTERED FUNCTIONAL STATES
SALIVARY GLAND SECRETORY MECHANISMS DURING NORMAL AND ALTERED FUNCTIONAL STATES
SALIVARY GLAND SECRETORY MECHANISMS DURING NORMAL AND ALTERED FUNCTIONAL STATES
SALIVARY GLAND SECRETORY MECHANISMS DURING NORMAL AND ALTERED FUNCTIONAL STATES
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