BEHAVIORAL PHARMACOLOGY AND TOXICOLOGY

行为药理学和毒理学项目旨在 在阐明神经药理学过程涉及 异常的大脑功能和技术的发展， 通过药物干预异常脑功能 操纵 这些研究涉及诱导异常的 行为和生理状态通过管理 药物和其他操纵，并试图改变行为， 生理状态通过药理学操作。 特别 感兴趣的主题是已知与 抗精神病药物的作用和药物引起的精神病。 这些 包括（i）苯环利定，其在人体内可诱导 类似精神分裂症的异常;（ii）降钙素和 钙通道抑制剂和激活剂，正在研究中 因为钙机制之间可能存在联系 以及慢性脑缺血引起的神经元功能的长期变化 （iii）癫痫发作和其他与癫痫有关的现象; 使君子酸型谷氨酸受体特别令人感兴趣 因为谷氨酸突触和 纹状体神经元上的多巴胺突触;（iv）各种神经元的变化 神经系统，特别是兴奋性氨基酸系统 研究了慢性精神抑制剂给药引起的 为了有助于了解的机制， 抗精神病药的作用。

The project on behavioral pharmacology and toxicology is aimed at the elucidation of neuropharmacological processes involved in abnormal brain function and at the development of techniques to intervene in abnormal brain function through pharmacological manipulations. These studies involve the induction of abnormal behavioral and physiological states through administration of drugs and other manipulations, and attempts to alter behavior and physiological states by pharmacological manipulations. Particular topics of interest are areas known to be associated with the actions of neuroleptic drugs and drug-induced psychoses. These include (i) phencyclidine, which in humans can induce abnormalities resembling schizophrenia; (ii) calcitonin and calcium-channel inhibitors and activators, are under investigation because of the possible relationships between calcium mechanisms and long-term changes in neuronal function induced by chronic neuroleptics; (iii) seizures and other phenomena related to the quisqualate type of glutamate receptors are of particular interest because of the close association between glutamate synapses and dopamine synapses on striatal neurons; (iv) changes in various neuronal systems particularly excitatory amino acid systems induced by chronic neuroleptic administration are investigated in order to contribute to an understanding of the mechanisms of action of neuroleptics.