BRAIN TISSUE TRANSPLANTATION

这些研究主要针对移植 含儿茶酚胺的组织，包括肾上腺髓质， 肿瘤细胞和胚胎脑组织进入大脑。 的 这些实验的目的是阐明 移植后这些组织和宿主的反应 移植的组织。 具体来说，这些实验 使用非灵长类动物模型（1）开发技术 脑组织移植在帕金森氏症的临床应用 （2）发展脑组织移植技术， 它们最终可能适用于其他疾病，例如 精神分裂症或阿尔茨海默病，如果这些疾病 充分理解，以允许此类应用;以及 (3)阐明控制大脑发育的因素 以及大脑对损伤或损伤的反应，特别是 强调黑质纹状体多巴胺系统。 在过去 在本报告所述年度，这些领域取得了重大进展。

These studies are primarily aimed at transplantation of catecholamine-containing tissues, including adrenal medulla, tumor cells, and embryonic brain tissue into the brain. The purpose of these experiments is to elucidate the properties of these tissues after transplantation and the response of the host brain to the transplanted tissues. Specifically, these experiments employ non-primate animal models to (1) develop the techniques of brain tissue transplantation for clinical use in Parkinson's disease; (2) develop brain tissue transplantation techniques so that they eventually may be applicable to other disorders, such as schizophrenia or Alzheimer's disease if and when these disorders become well enough understood to permit such applications; and (3) elucidate factors that control the development of the brain and responses of the brain to injury or impairment, with particular emphasis on the nigrostriatal dopamine system. During the past reporting year, significant progress has been made in these areas.