DNA vaccination using chemokine and costimulatory pathways as a treatment for chronic kidney disease

慢性肾病(CKD)是澳大利亚的一大负担。治疗大多是无效的。我们的针对炎症介质的DNA疫苗可以预防CKD。根据正在进行的研究，我们已经确定了5个与炎性细胞的招募和激活有关的候选分子。我们概述了针对这些分子产生DNA疫苗、提高它们的效力，并在代表人类CKD的3个最重要原因的模型中测试它们的研究。

Chronic kidney disease (CKD) is a great burden on Australia. Treatments are mostly ineffective. Our DNA vaccination against mediators of inflammation can protect against CKD. On the basis of ongoing studies we have identified 5 candidate molecules involved in recruitment and activation of inflammatory cells. We outline studies to generate DNA vaccines to these molecules, enhance their efficacy, and test them in models that represent the 3 most important causes of human CKD.