CANINE MODEL OF SEPTIC SHOCK

已建立了一种感染性休克的犬模型，以研究其病理生理学。 以及这一常见问题的治疗。 1)致病微生物的剂量效应--在以下范围内相同的微生物 正在给狗注射剂量以评估对血液动力学的影响 生物体的质量。 2)病原微生物的鉴定--多种病原微生物的等量 包括革兰氏阳性和革兰氏阴性在内的生物正在接受治疗 以确定不同的生物是否有不同的影响。 3)治疗效果--感染后的影响，容量的影响， 升压和各种抗生素对脓毒症结局的影响 评估过了。 这些研究是了解感染是如何引起的一项重要努力。 危及生命的血压下降及其治疗方法 为更有效地治疗此类感染而开发的。

A dog model of septic shock has been developed to study the pathophysiology and therapy of this common problem. 1) Effect of dose of causative organism - Identical organisms in a range of doses are being administered to dogs to assess influence of hemodynamics of the quality of organisms. 2) Identify of causative organism - Identical quantities of a variety of organisms including gram-positive and gram-negative are being administered to dogs to determine if different organisms have different effects. 3) Effect of therapy - Following infection, the effects of volume, pressors, and various antibiotics on the outcome of sepsis are being assessed. These studies are an important effort to understand how infection causes life-threatening drops in blood pressure and what therapies can be developed to treat such infections more effectively.