PHOTOTHERAPY OF MURINE OVARIAN CANCER BY HEMATOPORPHYRIN DERIVATIVE

血卟啉衍生物(Hpd)与红光的联合应用 目前正在作为一种抗癌治疗方式进行研究。一个 这种疗法的主要优点是所谓的肿瘤选择性。 而不是正常的组织反应。研究已经设计并正在进行 目前正在建立HPD在肿瘤组织和正常组织中的滞留 在小鼠模型中。一种起源于小鼠的卵巢肿瘤模型 已用于HPD的药效学测定，HPD的优化 给药、激光穿透、光和药物给药剂量和时间 腹膜腔。对不同波长的光的使用 腹水肿瘤模型的研究。人卵巢和肺异种移植 正在裸鼠身上进行研究。单线态氧的测量正在进行中 研究为剂量学铺平道路。犬对腔内的毒性 目前正在研究HPD和激光。

The use of hematoporphyrin derivative (HPD) in combination with red light is currently under investigation as an anti-cancer treatment modality. A major advantage of this therapy is the purported selectivity of tumor versus normal tissue response. Studies have been designed and are currently underway to establish HPD retention in tumor versus normal tissue in a murine model. An ovarian tumor model originating from a mouse has been used to determine the pharmacodynamics of HPD, optimization of HPD delivery, laser penetration, dose and timing of light and drug deliver into the peritoneal cavity. The use of different wavelengths of light is being studied on the ascites tumor model. Human xenografts from ovarian and lung are being studied in nude mice. Measurement of singlet oxygen is being studied to prepare the way for dosimetry. Dog toxicity to intracavitary HPD and laser light is being studied.