INTERFERON SYSTEM IN CELLULAR FUNCTION AND DISEASE

IFN蛋白可以修饰多种生物活性， 被认为是人体的调节蛋白之一。 现在有很多研究 表明干扰素是有效的免疫调节剂。 在过去一年中 我们一直在研究干扰素蛋白与细胞相互作用的方式， 免疫系统以及这种相互作用如何改变免疫反应， 免疫相关疾病。 利用免疫细胞化学分析，我们开发了一种灵敏的方法， 鉴定组织损伤部位的淋巴因子IFN-γ和IL-2。 我们已经确定了炎症眼中的淋巴因子，IFN-γ和IL-2 疾病 这些淋巴因子的存在与 淋巴细胞浸润主要是T细胞来源， 在浸润细胞和癌旁组织中表达MHC II类抗原， 视网膜色素上皮（RPE）细胞。 这是第一次证明淋巴因子，IFN-γ和I12在 局部自身免疫性疾病的部位。 这些观察结果可能表明 IFN-γ诱导的MHCII类抗原表达可能作为一种免疫调节剂， 局部放大系统在自身免疫性和炎症性眼病中的作用 一 更好地理解淋巴因子在相关机制中的作用 在自身免疫和炎症的发展可能是有益的， 这些疾病的治疗。

The IFN proteins can modify a variety of biological activities and are considered one of the body's regulatory proteins. Numerous studies now indicate that the IFN's are potent immunoregulators. During the past year we have been studying the ways in which IFN proteins interact with cells of the immune system and how this interaction may modify immune responses and immunologically related disorders. Using immunocytochemical analysis we have developed a sensitive method of identifying lymphokines, IFN-gamma and IL2, at the site of tissue damage. We have identified the lymphokines, IFN-gamma and IL2 in inflammatory eye diseases. The presence of these lymphokines is associated with a lymphocyte infiltrate predominantly of a T-cell origin and with the expression of MHC class II antigens on both the infiltrating cells and in the retinal pigment epithelial (rpe) cells. This is the first demonstration of lymphokines, IFN-gamma and I12 at the site of a localized autoimmune disease. These observations may indicate that IFN-gamma induced MHC classs II antigen expression may serve as a local amplification system in autoimmune and inflammatory eye disease. A better understanding of the role of lymphokines in the mechanisms involved in the development of autoimmunity and inflammation may be beneficial in the treatment of these diseases.