EFFECT OF NORMAL AGING ON LEFT VENTRICULAR FUNCTION

心血管功能随着年龄的增长而改变。 评估 为探讨年龄对左心室功能的影响，我们对66名正常志愿者进行了研究 (age 21-77）。 所有受试者的体格检查均正常， 检查、血压、心电图和超声心动图。 的 静息射血分数不随年龄变化，但随着年龄的增加， 最大仰卧运动时射血分数呈线性下降， 年龄的函数。 虽然收缩功能与年龄无关，但左心室收缩功能与年龄无关。 心室舒张期充盈随年龄增长而下降， 与年龄相关的局部左心室舒张期舒张功能的增加。 因此，衰老不影响静息时左心室收缩功能， 显著影响静息时左心室舒张功能， 以及最大运动量期间的射血分数反应。

Cardiovascular function is altered as a process of aging. To assess the effect of age on left ventricular function, we studied 66 normal volunteers (age 21-77) by radionuclide angiography. All subjects had normal physical exams, blood pressures, electrocardiograms, and echocardiograms. The resting ejection fraction did not vary with age, but the increase in ejection fraction during maximal supine exercise declined linearly as a function of age. Although systolic function was unrelated to age, left ventricular diastolic filling declined with age, which was associated with an age-related increase in regional left ventricular diastolic asynchrony. Thus, aging does not affect left ventricular systolic function at rest but significantly influences left ventricular diastolic function at rest as well as the ejection fraction response during maximum exercise.