PATHOPHYSIOLOGY OF CACHEXIA IN SARCOMA PATIENTS

这项研究旨在探索代谢需求的变化 强加给病人的肉瘤。自从软组织肉瘤被发现以来 是代谢活跃的肿瘤，NCI正在治疗大量的 这项研究将限于四肢和躯干肉瘤患者。 肉瘤患者。特别值得关注的是以下内容： 1.静息能量消耗是否因 肿瘤的存在吗？ 2.恶病质发病前体细胞质量有无变化？ 以前的研究仅限于病情严重的患者或少量患者。 病人的数量。这项研究将试图加深我们对 临床表现为隐匿性恶病质的病理生理学。 患者和志愿者将在年龄、性别和身体方面进行匹配 表面积。

This study is designed to explore alterations in metabolic demand which sarcomas imposed on patients. Since soft-tissue sarcomas have been shown to be metabolically active tumors and NCI is treating a large number of patients with extremity and truncal sarcomas this study will be limited to sarcoma patients. Of particular interest is the followin: 1. Is there any alteration in resting energy expenditure due to the presence of the tumor? 2. Is there any alteration in body cell mass prior to the onset of cachexia? Previous studies have been limited to very sick patients or small numbers of patients. This study will attempt to further our understanding of the pathophysiology of covert cachexia before it becomes clinically evident. Patients and volunteers will be matched with respect to age, sex, and body surface area.